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Treprostinil sodium

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SI-5363

Treprostinil sodium, >98% (HPLC)

CAS No. : [289480-64-4]

MDL No. : MFCD08141832

Synonyms : UT-15 sodium

IUPAC Name : Sodium 2-(((1R,2R,3aS,9aS)-2-hydroxy-1-((S)-3-hydroxyoctyl)-2,3,3a,4,9,9a-hexahydro-1H-cyclopenta[b]naphthalen-5-yl)oxy)acetate

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Chemical Properites
Mol. Formula :
C23H33NaO5
Mol. Weight :
412.50
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Treprostinil sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively. It is used to treat pulmonary arterial hypertension (PAH).

References : Whittle B. J. et al.: Biochem Pharmacol., 84(1), 68-75, 2012; Ferrantino M. et al.: Expert Opin Pharmacother., 12(16), 2583-93, 2011; Ghonem N. et al.: Am. J. Transplant., 11(11), 2508-16, 2011; Smadja D. M. et al.: Thromb Haemost., 114(4), 735-47, 2015; Kazemi Z. et al.: Mol Pharmacol., 89(6), 630-44, 2016; Nikam V. S. et al.: Eur Respir J. 36(6), 1302-14, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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