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Triamcinolone acetonide-d6

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SL-11756

Triamcinolone acetonide-d6, >98%

CAS No. : [352431-33-5]

IUPAC Name : (6aS,6bR,7S,8aS,8bS,11aR,12aS,12bS)-6b-Fluoro-7-hydroxy-8b-(2-hydroxyacetyl)-6a,8a-dimethyl-10,10-bis(methyl-d3)-1,2,6a,6b,7,8,8a,8b,11a,12,12a,12b-dodecahydro-4H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-4-one

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Chemical Properites
Mol. Formula :
C24H25D6FO6
Mol. Weight :
440.54
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Triamcinolone acetonide-d6 is a deuterium-labelled version of Triamcinolone acetonide. This can be used as an analytical labelled reference standard. Triamcinolone acetonide inhibits fibroblast growth factor (bFGF)-induced proliferation of retinal endothelial cells, reduces chondrocyte viability leading to cartilage destruction, and activates anti-inflammatory macrophages. Triamcinolone acetonide is also used to study diseases like atopic dermatitis.

References : Spandau U. H. M. et al.: British journal of ophthalmology, 89(6), 745-747, 2005; Euppayo T. et al.: In Vitro Cellular & Developmental Biology-Animal., 52(7), 723-735, 2016; Siebelt M. et al.: Arthritis research & therapy., 17(1), 1-13, 2015; Jensen J. M. et al.: Acta Dermato-Venereologica., 93(5), 515-519, 2013; Zhen X. et al.: Int. J. Biol Sci., 16(13), 2382-2391, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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