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Trilaciclib-d8 hydrochloride

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SL-11776

Trilaciclib-d8 hydrochloride, >98%

Synonyms : G1T28-d8 hydrochloride

IUPAC Name : 2'-((5-(4-Methylpiperazin-1-yl-2,2,3,3,5,5,6,6-d8)pyridin-2-yl)amino)-7',8'-dihydro-6'H-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one hydrochloride

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Chemical Properites
Mol. Formula :
C24H22D8N8O • HCl
Mol. Weight :
491.07
Appearance :
Solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : Trilaciclib-d8 dihydrochloride is a deuterium-labelled version of Trilaciclib dihydrochloride. This can be used as an analytical labelled reference standard. Trilaciclib is an oral CDK4/6 inhibitor. It effectively suppresses tumour cell proliferation and helps reduce the blood-related toxicity associated with chemotherapy. Additionally, Trilaciclib dihydrochloride lessens both apoptosis and myelosuppression caused by 5-Fluorouracil (5-FU) chemotherapy.

References : Bisi J. E. et al.: Mol Cancer Ther., 15(5), 783-93, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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