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Troglitazone

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SI-6580

Troglitazone, >98% (HPLC)

CAS No. : [97322-87-7]

Synonyms : CS-045

IUPAC Name : 5-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy)benzyl)thiazolidine-2,4-dione

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Chemical Properites
Mol. Formula :
C24H27NO5S
Mol. Weight :
441.54
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Troglitazone activates PPARγ with EC50 values of 550 nM (human) and 780 nM (murine). It exhibits anticancer properties and enhances metabolic regulation, contributing to the prevention and inhibition of type 2 diabetes development.

References : Willson T. M. et al.: J. Med. Chem., 43(4), 527-50, 2000; Fujita M. et al.: J. Exp. Clin. Cancer Res., 36(1), 91, 2017; Nazim U. M. et al.: Oncotarget., 8(16), 26819-26831, 2017; Knowler. W. C. et al.: Diabetes, 54(4), 1150-6, 2005.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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