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Tropifexor

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SI-6017

Tropifexor, >98% (HPLC)

CAS No. : [1383816-29-2]

Synonyms : LJN452

IUPAC Name : 2-(3-((5-Cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carboxylic acid

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Chemical Properites
Mol. Formula :
C29H25F4N3O5S
Mol. Weight :
603.59
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Tropifexor is a highly potent and agonist of the farnesoid X receptor (FXR), for the treatment of cholestatic liver diseases and nonalcoholic steatohepatitis (NASH).

References : Tully C. D. et al.: J. Med. Chem., 60(24), 9960-9973, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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