TTBK1-IN-1

SI-6614

TTBK1-IN-1, >98% (HPLC)

CAS No. : [2735015-60-6]

IUPAC Name : (S)-1-(1-(2-Amino-6-methoxypyrimidin-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-yl)-3-methylpent-1-yn-3-ol

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This potently inhibits TTBK1 with low‑nanomolar activity (IC₅₀ = 2.7 nM) and is brain‑penetrant, supporting its use in mechanistic studies of Alzheimer’s disease and tau‑driven neurodegeneration. Its built‑in alkyne group enables CuAAC click‑chemistry coupling with azide‑containing molecules.

References : Tamara Halkina et al.: J. Med. Chem., 64(9), 6358-6380, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.