TYK2 inhibitor

SI-6167

TYK2 inhibitor, >98% (HPLC)

CAS No. : [2095655-09-1]

IUPAC Name : 3-(4-(5-Fluoro-2-((1-((trifluoromethyl)sulfonyl)-1H-indol-5-yl)amino)pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a potent, selective TYK2 inhibitor (IC₅₀ = 9 nM) with strong JAK‑family selectivity, good functional activity in JAK/STAT assays, and moderate metabolic stability. In a DSS colitis model, it reduced IL‑6 and TNF‑α and improved inflammatory symptoms, supporting its potential as a TYK2‑directed therapeutic for immune‑mediated diseases.

References : Zhang C. et al.: J. Med. Chem., 64(4), 1966-1988, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.