TYK2 inhibitor

SI-6418

TYK2 inhibitor, >98% (HPLC)

IUPAC Name : 3-(4-(5-Fluoro-2-((1-((trifluoromethyl)sulfonyl)-1H-indol-6-yl)amino)pyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a potent, selective TYK2 inhibitor (IC₅₀ = 9 nM) from an indole–pyrimidine–pyrazole series designed to modulate IL‑23, IL‑12, and Type I IFN signaling. It shows clean JAK‑family selectivity, good functional potency in JAK/STAT assays, moderate metabolic stability, and clear in vivo anti‑inflammatory efficacy in a DSS colitis model—supporting its advancement as a TYK2‑directed therapeutic for immune‑mediated diseases.

References : Zhang C. et al.: J. Med. Chem., 64(4), 1966-1988, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.