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Umbralisib

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SI-5328

Umbralisib, >98% (HPLC)

CAS No. : [1532533-67-7]

MDL No. : MFCD28386165

Synonyms : TGR-1202; Rp-5264

IUPAC Name : (S)-2-(1-(4-Amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

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Chemical Properites
Mol. Formula :
C31H24F3N5O3
Mol. Weight :
571.56
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Umbralisib is a novel, next generation PI3Kδ inhibitor, inhibits PI3Kδ activity in enzyme and cell based assays with IC50 and EC50 values of 22.2 & 24.3 nM, respectively. Umbralisib medication is used for the treatment of marginal zone lymphoma and follicular lymphoma.

References : Deng C. et al.: Blood 129(1), 88-99, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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