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URB-937

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SI-7700

URB-937, >98% (HPLC)

CAS No. : [1357160-72-5]

IUPAC Name : 3'-Carbamoyl-6-hydroxy-[1,1'-biphenyl]-3-yl cyclohexylcarbamate

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100MG248.00
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Chemical Properites
Mol. Formula :
C20H22N2O4
Mol. Weight :
354.41
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : URB-937 potently inhibits peripheral FAAH (IC50 = 26.8 nM) and increases anandamide levels outside the CNS. Its lack of blood–brain barrier penetration prevents inhibition of brain FAAH, giving URB937 a peripherally selective pharmacological profile.

References : Jason R. Clapper et al.: Nat. Neurosci., 13(10), 1265-70, 2010; Vozella V. et al.: J. Pharm Pharmacol., 71(12), 1762-1773, 2019; Moreno-Sanz G. et al.: Br. J. Pharmacol., 167(8), 1620-8, 2012; Li R. et al.: Inflammation, 40(4), 1254-1263, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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