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V-0219 hydrochloride

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SI-7024

V-0219 hydrochloride, >98% (HPLC)

CAS No. : [2922283-73-4]

IUPAC Name : 4-((1-((3-(4-(Trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)methyl)piperidin-3-yl)methyl)morpholine hydrochloride

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Chemical Properites
Mol. Formula :
C20H25F3N4O2 • HCl
Mol. Weight :
446.9
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : V‑0219 hydrochloride functions as an orally active GLP‑1R PAM that amplifies GLP‑1‑driven cAMP generation and insulin release in a glucose‑dependent manner. It improves glucose handling in normal and diabetic rodents, making it a valuable tool compound for investigating metabolic mechanisms relevant to obesity‑associated diabetes.

References : Decara J. M. et al.: J. Med. Chem., 65(7), 5449-5461, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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