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Vacquinol-1

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SI-7976

Vacquinol-1, >98% (HPLC)

CAS No. : [5428-80-8]

Synonyms : NSC-13316

IUPAC Name : (2-(4-Chlorophenyl)quinolin-4-yl)(piperidin-2-yl)methanol

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Chemical Properites
Mol. Formula :
C21H21ClN2O
Mol. Weight :
352.86
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Vacquinol‑1 is a MKK4‑specific activator that stimulates the MAPK signaling pathway, leading to broad antitumor effects. It inhibits cancer‑cell growth, migration, and colony formation, and robustly induces apoptosis. Vacquinol‑1 is widely used in studies of hepatocellular carcinoma and other cancers where MAPK‑pathway modulation is therapeutically relevant.

References : Sun S. L. et al.: Mol Med Rep., 18(1), 557-563, 2018; Wu C. et al.: Life Sci., 239, 116881, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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