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Vazegepant impurity 5

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Vazegepant impurity 5, >98%

CAS No. : [3019989-24-0]

Synonyms : Zavegepant impurity 5

IUPAC Name : (R)-N-(3-(6-Methyl-1H-indazol-4-yl)-1-oxo-1-(4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidin-1-yl)propan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide

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Chemical Properites
Mol. Formula :
C40H41N7O4
Mol. Weight :
683.81
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Vazegepant, which is an orally active CGRP receptor antagonist used in migraine research and can also be given intranasally. CGRP plays a key role in migraine pathophysiology.

References : Moreno-Ajona D. et al.: Curr Opin Neurol., 33(3), 309-315, 2020; Gene M. D. et al.: Med Chem., 63(13), 6600-6623, 2020; Capi M. et al.: Springer International Publishing, 67-72, 2022; Jessica Barreto R. D. S. et al.: Eur. J. Pharmacol., 922, 174902, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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