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Venetoclax descarboxyl impurity

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Venetoclax descarboxyl impurity, >98%

IUPAC Name : 5-(3-(4-((4'-Chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-yl)methyl)piperazin-1-yl)phenoxy)-1H-pyrrolo[2,3-b]pyridine

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In Stock  Estimated to ship on 20 September 2026
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Chemical Properites
Mol. Formula :
C32H35ClN4O
Mol. Weight :
527.11
Appearance :
Pale brown solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Venetoclax, which is a highly potent, selective and orally bioavailable B-cell lymphoma 2 (BCL-2) inhibitor. It is used to treat chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), and acute myeloid leukemia (AML).

References : Souers A. J. et al.: Nat Med., 19(2), 202-8, 2013; Peirs S. et al.: Blood 124(25), 3738-47, 2014; Bi C. et al.: Haematologica, 102(4), 755-764, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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