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VER-246608

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SI-5495

VER-246608, >98% (HPLC)

CAS No. : [1684386-71-7]

MDL No. : MFCD28411365

IUPAC Name : N-(4-(2-Chloro-5-methylpyrimidin-4-yl)phenyl)-N-(4-((2,2-difluoroacetamido)methyl)benzyl)-2,4-dihydroxybenzamide

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Chemical Properites
Mol. Formula :
C28H23ClF2N4O4
Mol. Weight :
552.96
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : VER-246608 is a potent and ATP-competitive inhibitor of pyruvate dehydrogenase kinase (PDK) with IC50s of 35 nM, 40 nM, 84 nM, and 91 nM for PDK-1, PDK-3, PDK-2, and PDK-4, respectively.

References : Moore J. D. et al.: Oncotarget., 5(24), 12862-76, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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