VGCC blocker 1

SI-6147

VGCC blocker 1, >98% (HPLC)

CAS No. : [461432-09-7]

IUPAC Name : 6-(4-Ethoxyphenyl)-1,4,5,7-tetramethyl-6H-pyrrolo[3,4-d]pyridazine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a Cavα2δ‑1 blocker, a chemotype used to modulate voltage‑gated calcium channel auxiliary subunit α2δ‑1. By inhibiting Cavα2δ‑1, this scaffold can reduce aberrant neuronal excitability and is relevant to neuropathic pain and other calcium‑channel–driven disorders, serving as a tool compound or lead structure in Cavα2δ‑1‑targeted drug discovery.

References : Stearns B. A. et al.: Bioorg. Med. Chem. Lett., 14(5), 1295-1298, 2004; Hu T. et al.: Bioorg. Med. Chem. Lett., 14(9), 2031-2034, 2004; Chen C. et al.: Bioorg. Med. Chem. Lett., 16(3), 746-749, 2006.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.