VGCC blocker 2

SI-6148

VGCC blocker 2, >98% (HPLC)

IUPAC Name : 2-(4-Ethoxy-2-fluorophenyl)-7-(3-methoxyazetidin-1-yl)-3,4-dimethyl-2H-pyrazolo[3,4-d]pyridazine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is an optimized α₂δ‑1 ligand, designed to overcome high P‑gp efflux and rapid in vivo clearance. It exhibits an improved DMPK profile, strong in vivo analgesic efficacy, and high selectivity for α₂δ‑1 over α₂δ‑2. Computational tools—including an in‑house P‑gp prediction platform and MetaSite® metabolic hotspot analysis—guided its refinement, yielding a more developable α2δ‑1‑targeted analgesic lead.

References : Myatt J. W. et al.: Bioorg. Med. Chem. Lett., 20(15), 4683-4688, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.