VGCC blocker 3

SI-6149

VGCC blocker 3, >98% (HPLC)

IUPAC Name : (S)-2-(Ethylamino)-6-(3-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)-6,7,7a,8,9,10-hexahydro-5H-pyrimido[5,4-f]pyrrolo[1,2-a][1,4]diazepin-5-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This pyrimidodiazepinone tricyclic derivative is a Cavα2δ‑1 blocker, part of a chemotype designed to modulate the α₂δ‑1 auxiliary subunit of voltage‑gated calcium channels. By selectively engaging α₂δ‑1, it can reduce aberrant neuronal excitability and serves as a promising scaffold for neuropathic‑pain drug discovery, offering a structurally distinct alternative to classical α₂δ ligands.

References : Diaz L. J. et al.: J. Med. Chem., 64(4), 2167-2185, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.