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Vigabatrin related compound B

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Vigabatrin related compound B, >98%

CAS No. : [1379403-11-8]

IUPAC Name : (E)-2-(2-Aminoethyl)but-2-enoic acid hydrochloride

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Chemical Properites
Mol. Formula :
C6H11NO2 • HCl
Mol. Weight :
165.62
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
H2O
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Vigabatrin, which is a vinyl derivative of the inhibitory neurotransmitter GABA, that functions as an orally active and irreversible inhibitor of GABA transaminase. As an antiepileptic agent, Vigabatrin increases GABA concentrations in the brain by inhibiting its catabolism through GABA transaminase inhibition.

References : Broeer S. et al.: Neurobiology of Disease, 46(2), 362-376, 2012; Jakob P. et al.: Int. J. Pharm., 473(1-2), 395-7, 2014; Gaily E. Expert Review of Neurotherapeutics, 12(3), 275-286, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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