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SI-8168

Vilagletistat, >98% (HPLC)

CAS No. : [1542132-88-6]

Synonyms : ZED-1227

IUPAC Name : Methyl (S,E)-7-((1-(2-((2-ethylbutyl)amino)-2-oxoethyl)-2-oxo-1,2-dihydropyridin-3-yl)amino)-6-(1-methyl-1H-imidazole-5-carboxamido)-7-oxohept-2-enoate

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Chemical Properites
Mol. Formula :
C26H36N6O6
Mol. Weight :
528.61
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : ZED‑1227 selectively inhibits TG2 with nanomolar potency (IC50 = 45 nM) and prevents inflammation‑induced increases in TG2 expression and activity. It is valuable for probing TG2‑dependent mechanisms in celiac disease.

References : Encalada M. et al.: Gastroenterology, 154(6), S-490, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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