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Voriconazole-d3

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SL-11831

Voriconazole-d3, >98%

CAS No. : [1217661-14-7]

Synonyms : UK-109496-d3

IUPAC Name : (2R,3S)-2-(2,4-Difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-4,4,4-d3-2-ol

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Chemical Properites
Mol. Formula :
C16H11D3F3N5O
Mol. Weight :
352.34
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : Voriconazole-d3 is a deuterium-labelled version of Voriconazole. This can be used as an analytical labelled reference standard. Voriconazole is a second-generation, broad-spectrum triazole antifungal agent that functions by inhibiting fungal ergosterol biosynthesis. Its antifungal mechanism involves the suppression of 14-α-lanosterol demethylation, a process mediated by fungal cytochrome P450 enzymes. Additionally, Voriconazole is capable of penetrating the blood-brain barrier (BBB).

References : Nickie D. G. et al.: Proc (Bayl Univ Med Cent), 16(2), 241-248, 2003; Michael E. H. et al.: Antimicrob Agents Chemother., 57(11), 5271-5276, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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