Voriconazole impurity 15

SL-11836

Voriconazole impurity 15, >98%

CAS No. : [321589-00-8]

IUPAC Name : 2-(2,4-Difluorophenyl)-3-(5-fluoro-6-(1-(5-fluoropyrimidin-4-yl)ethyl)pyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol

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Applications : This is an impurity of Voriconazole, which is a second-generation, broad-spectrum triazole antifungal agent that functions by inhibiting fungal ergosterol biosynthesis. Its antifungal mechanism involves the suppression of 14-α-lanosterol demethylation, a process mediated by fungal cytochrome P450 enzymes. Additionally, Voriconazole is capable of penetrating the blood-brain barrier (BBB).

References : Nickie D. G. et al.: Proc (Bayl Univ Med Cent), 16(2), 241-248, 2003; Michael E. H. et al.: Antimicrob Agents Chemother., 57(11), 5271-5276, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.