Vps34 (class III PI3K) inhibitor

SI-7147

Vps34 (class III PI3K) inhibitor, >98% (HPLC)

CAS No. : [2119569-21-8]

IUPAC Name : (S)-9-(3-Methyl-2-oxobutyl)-2-((R)-3-methylmorpholino)-8-(trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Thi is a potent and highly selective Vps34 (class III PI3K) inhibitor derived from a tetrahydropyrimido­pyrimidinone scaffold. It demonstrates strong Vps34 inhibitory activity with excellent selectivity over class I PI3Ks and a 370‑kinase panel, driven by unique morpholine‑based molecular features confirmed by X‑ray co‑crystal structure. It shows favorable mouse PK and induces sustained Vps34 inhibition in vivo, making it a valuable optimized tool compound for studying autophagy, vesicle trafficking, and cancer biology.

References : Pasquier B. et al.: J. Med. Chem., 58(1), 376-400, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.