VTP-50469

SI-7715

VTP-50469, >98% (HPLC)

CAS No. : [2169916-18-9]

Synonyms : SNDX-50469

IUPAC Name : 5-Fluoro-N,N-diisopropyl-2-((4-(7-(((1r,4r)-4-(methylsulfonamido)cyclohexyl)methyl)-2,7-diazaspiro[3.5]nonan-2-yl)pyrimidin-5-yl)oxy)benzamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : VTP-50469 potently and selectively inhibits the menin–MLL interaction with picomolar affinity (K_i = 104 pM). Its oral activity and strong suppression of MLL‑driven transcription translate into pronounced anti‑leukemia efficacy.

References : Krivtsov A. V. et al.: Cancer Cell, 36(6), 660-673.e11, 2019; Andrei V. Krivtsov A. V. et al.: Cancer Resceach, 78(13), Supplement,4958, 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.