VU-0453379

SI-7028

VU-0453379, >98% (HPLC)

CAS No. : [1638646-27-1]

IUPAC Name : (S)-2-Cyclopentyl-N-((1-isopropylpyrrolidin-2-yl)methyl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrido[3,4-b]indole-4-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : VU-0453379 is a brain‑penetrant GLP‑1R PAM (EC₅₀= 1.3 µM) that amplifies GLP‑1‑mediated signaling, promotes receptor internalization, and stimulates insulin release in primary mouse islets. It enhances endogenous GLP‑1R function and reverses catalepsy in animal models, making it a valuable tool for studying metabolic and neurological disorders, including type 2 diabetes and Parkinson’s disease.

References : Morris L. C. et al.: J. Med. Chem., 57(23), 10192-7, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.