VVD-118313

SI-8132

VVD-118313, >98% (HPLC)

CAS No. : [2875046-27-6]

Synonyms : Allosteric JAK1 inhibitor

IUPAC Name : 1-((S)-3-(3,4-Dichlorophenyl)piperidin-1-yl)-3-((R)-1-(methylsulfonyl)pyrrolidin-3-yl)prop-2-yn-1-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : VVD‑118313 selectively inhibits JAK1 by covalently targeting an allosteric cysteine residue, effectively blocking trans‑phosphorylation and cytokine‑dependent signaling cascades. It is valuable for cancer research and functions as a click‑chemistry reagent due to its terminal alkyne group, which supports CuAAC reactions with azide‑containing partners.

References : Kavanagh E. M. et al.: Nat. Chem. Biol., 18(12), 1388-1398, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.