VX-984

SI-6845

VX-984, >98% (HPLC)

CAS No. : [1476074-39-1]

Synonyms : M-9831

IUPAC Name : (S)-N-Methyl-8-(1-((2'-methyl-[4,5'-bipyrimidin]-6-yl-4',6'-d2)amino)propan-2-yl)quinoline-4-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : VX‑984 selectively inhibits DNA‑PK with strong oral activity and demonstrated BBB penetration. It disrupts NHEJ‑mediated DNA repair, leading to elevated DNA double‑strand breaks and enhanced vulnerability of tumor cells. Its pharmacological profile supports its use in glioblastoma and NSCLC research. VX‑984 is a de novo deuterated analog with improved metabolic stability.

References : Timme C. R. et al.: Mol. Cancer Ther., 17(6), 1207-1216, 2018; Khan A. J, et al.: Oncotarget., 9(40),25833-25841, 2018; Diane Boucher. et al.: Cancer Res. 76 (14), 3716, 2016; Russak E. M. et al.: Ann Pharmacother., 53(2), 211-216, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.