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W-6134

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SI-7535

W-6134, >98% (HPLC)

CAS No. : [2983540-55-0]

IUPAC Name : N-(2'-Chloro-4'-(2-(4-(ethylsulfonyl)phenyl)acetamido)-[1,1'-biphenyl]-2-yl)acrylamide

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Chemical Properites
Mol. Formula :
C25H23ClN2O4S
Mol. Weight :
482.98
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : W-6134 covalently targets RORγ with high potency and excellent isoform selectivity. It blocks RORγ‑driven transcription, reduces CRPC cell proliferation, impairs colony formation, and promotes apoptosis, making it suitable for research on RORγ‑dependent signaling in castration‑resistant prostate cancer.

References : Fang W. et al.: J. Med. Chem., 67(2), 1481-1499, 2024.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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