WDR5-IN-1

SI-5649

WDR5-IN-1, >98% (HPLC)

CAS No. : [2408842-51-1]

IUPAC Name : 2-(3,5-Dimethoxybenzyl)-5-(4-fluoro-2-methylphenyl)-7-((2-imino-3-methyl-2,3-dihydro-1H-imidazol-1-yl)methyl)-3,4-dihydroisoquinolin-1(2H)-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 05 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 05 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 05 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 05 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 05 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 05 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 05 October 2026

Applications : WDR5-IN-1 is a potent and selective WD repeat domain 5 (WDR5) inhibitor, with a Kd of <0.02 nM. WDR5-IN-1 inhibits MLL1 histone methyltransferase (HMT) activity with an IC50 of 2.2 nM. WDR5-IN-1 diminishes MYC recruitment at WDR5-displaced genes and exhibits potent anti-proliferative effects in CHP-134 (neuroblastoma) and Ramos (Burkitt’s lymphoma) lines.

References : Tian J. et al.: J. Med Chem., 63(2), 656-675, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.