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SI-7761

WX-8, >98% (HPLC)

CAS No. : [232935-92-1]

Synonyms : RO-914714

IUPAC Name : (Z)-4-(2-((3H-Indol-3-ylidene)methyl)hydrazineyl)-6-morpholino-N-phenyl-1,3,5-triazin-2-amine

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Chemical Properites
Mol. Formula :
C22H22N8O
Mol. Weight :
414.47
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : WX-8 potently inhibits PIKFYVE (K_d = 0.9 nM) with weaker activity toward PIP4K2C (340 nM). It disrupts lysosomal fission without altering homotypic lysosomal fusion and is used to investigate lysosomal and autophagy‑regulated mechanisms in cancer models.

References : Roy A. et al.: Cells, 13(13), 1096, 2024; Sharma G. et al: Autophagy, 15(10), 1694-1718, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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