XE-991

SI-7659

XE-991, >98% (HPLC)

CAS No. : [122955-42-4]

IUPAC Name : 10,10-Bis(pyridin-4-ylmethyl)anthracen-9(10H)-one

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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : XE-991 provides a high‑purity analytical reference for XE-991. The parent compound potently inhibits Kv7.1, Kv7.2, and Kv7.2/7.3 channels (IC₅₀= 0.6–0.75 µM) and blocks the neuronal M‑current (IC₅₀= 0.98 µM), making it a widely used tool for probing KCNQ‑mediated control of neuronal excitability. The standard is intended for research and analytical use.

References : Wang H. S. et al.: Science, 282(5395), 1890-3, 1998; Zaczek R. et al.: J. Pharmacol. Exp. Ther., 285(2), 724-30, 1998.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.