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XMD8-92

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SI-6007

XMD8-92, >98% (HPLC)

CAS No. : [1234480-50-2]

MDL No. : MFCD18782742

IUPAC Name : 2-((2-Ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5,11-dimethyl-5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one

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Chemical Properites
Mol. Formula :
C26H30N6O3
Mol. Weight :
474.57
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : XMD8-92 is a potent and selective dual inhibitor of big map kinase (BMK1, ERK5) and bromodomain-containing proteins (BRDs, BET) with anti-cancer activity.

References : Yang Q. et al.: Cancer Cell., 18(3), 258-67, 2010; Yang Q. et al.: Clin Cancer Res., 17(11), 3527-32, 2011; Lin E. C. et al.: Proc Natl Acad Sci U S A. 113(42), 11865-11870, 2016; Umapathy G. et al.: Sci Signal. 7(349), ra102, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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