Y-27632 dihydrochloride

SI-6297

Y-27632 dihydrochloride, >98% (HPLC)

CAS No. : [129830-38-2]

IUPAC Name : (1R,4r)-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexane-1-carboxamide dihydrochloride

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Y‑27632 dihydrochloride selectively inhibits ROCK1/2 with sub‑micromolar potency and is orally active and ATP‑competitive. Beyond its effects on Rho‑kinase signaling, it shows antiepileptic activity, making it relevant for studies of neuronal excitability and seizure modulation.

References : Tada S. et al.: J. Hepatol., 34(4), 529-36, 2001; Inan S. et al.: Br. J. Pharmacol., 155(1), 44-51, 2008; Xue Z. W. et al.: Chin. Med. J. (Engl)., 125(18), 3332-5, 2012; Ishizaki T. et al.: Mol. Pharmacol., 57(5), 976-83, 2000.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.