YH-6

SI-7186

YH-6, >98% (HPLC)

IUPAC Name : N-((S)-1-(2-((R)-2-Chloro-2-fluoroacetyl)-2-(((S)-2-oxopyrrolidin-3-yl)methyl)hydrazineyl)-4-methyl-1-oxopentan-2-yl)-4-fluoro-1H-indole-2-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : YH‑6 is a covalent SARS‑CoV‑2 3CL^pro inhibitor featuring a chlorofluoroacetamide (CFA) warhead on an aza‑peptide scaffold. The (R)‑configured CFA enables covalent binding to Cys145 at the catalytic center, yielding strong antiviral potency comparable to nirmatrelvir. YH‑6 robustly blocks SARS‑CoV‑2 replication in infected cells and shows favorable pharmacokinetic properties, supporting its potential as a lead compound for COVID‑19 therapeutic development.

References : Hirose Y. et al.: J. Med. Chem., 65(20), 13852-13865, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.