YKL-5-124

SI-7820

YKL-5-124, >98% (HPLC)

CAS No. : [1957203-01-8]

IUPAC Name : (S)-3-(4-Acrylamidobenzamido)-N-(2-(dimethylamino)-1-phenylethyl)-6,6-dimethyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : YKL‑5‑124 irreversibly and covalently inhibits CDK7 with IC₅₀ values of 53.5 nM (CDK7) and 9.7 nM (CDK7/Mat1/CycH). It is >100‑fold more selective for CDK7 than for CDK9 or CDK2 and remains inactive against CDK12 and CDK13. Biologically, it triggers strong cell‑cycle arrest, suppresses E2F‑driven transcription, and minimally affects RNA polymerase II phosphorylation, making it a powerful probe for CDK7‑regulated pathways.

References : Olson C. M. et al.: Cell. Chem. Biol., 26(6), 792-803.e10, 2019.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.