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Zanubrutinib

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SI-5471

Zanubrutinib, >98% (HPLC)

CAS No. : [1691249-45-2]

Synonyms : BGB-3111

IUPAC Name : (S)-7-(1-Acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide

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Chemical Properites
Mol. Formula :
C27H29N5O3
Mol. Weight :
471.56
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Zanubrutinib is a potent, specific and irreversible BTK inhibitor that has been shown to have a lower off-target inhibitory activity on other kinases, including ITK, JAK3 and EGFR. Zanubrutinib is used to treat mantle cell lymphoma.

References : Tam C. et al.: Blood 126, 832,2015; Li N. et al.: AACR Cancer Res., 75(15 Suppl), Abstract nr 2597, 2015; .Wu J. et al.: J. Hematol Oncol., 9(1), 80, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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