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Zanubrutinib impurity 5 (S-isomer)

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Zanubrutinib impurity 5 (S-isomer), >98%

CAS No. : [2190506-59-1]

IUPAC Name : (S)-2-(4-Phenoxyphenyl)-7-(piperidin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carbonitrile

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In Stock  Estimated to ship on 20 September 2026
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Chemical Properites
Mol. Formula :
C24H25N5O
Mol. Weight :
399.5
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Zanubrutinib, which is a potent, specific and irreversible BTK inhibitor that has been shown to have a lower off-target inhibitory activity on other kinases, including ITK, JAK3 and EGFR. Zanubrutinib is used to treat mantle cell lymphoma.

References : Tam C. et al.: Blood 126, 832, 2015; Li N. et al.: AACR Cancer Res., 75(15 Suppl), Abstract nr 2597, 2015; Wu J. et al.: J. Hematol Oncol., 9(1), 80, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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