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Zasocitinib

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SI-7394

Zasocitinib, >98% (HPLC)

CAS No. : [2272904-53-5]

Synonyms : NDI-034858; TAK-279

IUPAC Name : N-((1R,2R)-2-Methoxycyclobutyl)-7-(methylamino)-5-((2-oxo-2H-[1,2'-bipyridin]-3-yl)amino)pyrazolo[1,5-a]pyrimidine-3-carboxamide

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Chemical Properites
Mol. Formula :
C23H24N8O3
Mol. Weight :
460.50
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Zasocitinib selectively engages the TYK2 JH2 domain with sub‑nanomolar affinity (Kd < 200 pM), providing a potent tool for modulating TYK2‑dependent cytokine signaling.

References : Leit S. et al.: J. Med. Chem., 66(15), 10473-10496, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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