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Zebularine

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SI-6678

Zebularine, >98% (HPLC)

CAS No. : [[3690-10-6]]

Synonyms : 4-Deoxyuridine; NSC-309132

IUPAC Name : 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

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Chemical Properites
Mol. Formula :
C9H12N2O5
Mol. Weight :
228.2
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Zebularine is a uridine‑derived nucleoside analog that inhibits DNA methyltransferases and blocks cytidine deaminase (Ki= 0.95 µM). Its dual activity makes it a useful tool for probing epigenetic regulation and pyrimidine metabolism.

References : Champion C. et al.:PLoS One., 5(8), e12388, 2010; Cheng J. C. et al.: J. Natl. Cancer Inst., 95(5), 399-409, 2003; Billam M. et al.: Breast Cancer Res. Treat., 120(3), 581-92, 2010; Lemaire M. et al.: Cancer Chemother. Pharmacol., 63(3), 411-6, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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