Zegocractin

SI-6872

Zegocractin, >98% (HPLC)

CAS No. : [1713240-67-5]

Synonyms : CM-4620

IUPAC Name : N-(5-(6-Chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)pyrazin-2-yl)-2-fluoro-6-methylbenzamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Zegocractin selectively inhibits CRAC channel activity, targeting Orai1/STIM1 and Orai2/STIM1 with IC₅₀ values of 119 nM and 895 nM, respectively. It is a valuable tool for probing Ca²⁺‑dependent immune pathways and Orai‑mediated signaling.

References : Waldron R. T. et al.: J. Physiol., 597(12), 3085-3105, 2019;
Uchimura T. et al. Biomedicines., 9(11), 1589, 2021; Gerasimenko J. V. et al.: Function. (Oxf)., 3(2), zqac002, 2022; Wen L. et al.: Gastroenterology 149, 481-92, e7.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.