Zelebrudomide

SI-7570

Zelebrudomide, >98% (HPLC)

CAS No. : [2416131-46-7]

Synonyms : NX-2127

IUPAC Name : 3-((4-(1-(((3S)-1-(2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)pyrrolidin-3-yl)methyl)piperidin-4-yl)phenyl)amino)-5-(piperidin-1-yl)pyrazine-2-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Zelebrudomide is a potent BTK‑directed PROTAC that effectively suppresses growth of BTK C481S mutant TMD8 cells and degrades IKZF1 and IKZF3 at nanomolar concentrations. It also stimulates T‑cell activation and boosts IL‑2 production, highlighting its dual activity on BTK signaling and IKZF‑mediated immune regulation.

References : Robbins D. W. et al.: J. Med. Chem., 67(4), 2321-2336, 2024.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.