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Zileuton β-D-glucuronide

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SL-7079

Zileuton β-D-glucuronide, >98%

CAS No. : [141056-63-5]

Synonyms : 1-O-[(Aminocarbonyl)(1-benzo[b]thien-2-ylethyl)amino]-β-D-glucopyranuronic acid; Zileuton glucuronide

IUPAC Name : (2S,3S,4S,5R,6S)-6-((1-(1-(benzo[b]thiophen-2-yl)ethyl)ureido)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid

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Chemical Properites
Mol. Formula :
C17H20N2O8S
Mol. Weight :
412.41
Appearance :
Solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a glucuronide metabolite of Zileuton, which is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation. It is used to decrease the symptoms of asthma. Zileuton induces apoptosis while inhibits ferroptosis.

References : Rossi A. et al.: Br. J. Pharmacol., 161(3), 555-570, 2010; Bertran X. et al.: Gut., 38(6), 899-904, 1996; Genovese T. et al.: Br. J. Pharmacol., 153(3), 568-582, 2008; Patel N. S. et al.: Mol Pharmacol., 66(2), 220-227, 2004; Rao N. L. et al.: J. Pharmacol Exp Ther., 321(3), 1154-1160, 2007; Yang Liu et al.: Biol Pharm Bull., 38(8), 1234-9, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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