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ZLY-28

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SI-7905

ZLY-28, >98% (HPLC)

CAS No. : [3004676-77-8]

IUPAC Name : 1-(4'-((5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)-[1,1'-biphenyl]-3-yl)cyclopropane-1-carboxylic acid

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Chemical Properites
Mol. Formula :
C29H23Cl2NO4
Mol. Weight :
520.41
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : ZLY-28 functions as an intestinal‑restricted, orally active dual modulator of FXR and FABP1, exhibiting strong anti‑NASH activity. Its localized intestinal action makes it valuable for probing FXR/FABP1‑dependent pathways in NASH pathogenesis.

References : Ren Q. et al.: J. Med. Chem., 66(9), 6082-6104, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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