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Zosuquidar

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SI-6212

Zosuquidar, >98% (HPLC)

CAS No. : [167354-41-8]

Synonyms : RS-33295-198; LY-335979

IUPAC Name : (R)-1-(4-((1aR,6r,10bS)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c][7]annulen-6-yl)piperazin-1-yl)-3-(quinolin-5-yloxy)propan-2-ol

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Chemical Properites
Mol. Formula :
C32H31F2N3O2
Mol. Weight :
527.62
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Zosuquidar inhibits P‑gp with nanomolar potency (Ki = 59 nM), improving intracellular drug accumulation and overcoming efflux‑mediated resistance. It shows antitumor effects and is an important tool compound for AML research.

References : Dantzig A. H. et al.: Cancer Res., 56(18), 4171-9, 1996; Tang R. et al.: BMC Cancer, 8, 51, 2008; Cripe D. L. et al.: Blood, 116(20), 4077-85, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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