Zotiraciclib

SI-7419

Zotiraciclib, >98% (HPLC)

CAS No. : [1023090-08-5]

Synonyms : TG-02

IUPAC Name : (E)-6-Methyl-12-oxa-3,6-diaza-2(4,2)-pyrimidina-1,4(1,3)-dibenzenacyclododecaphan-8-ene

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Zotiraciclib potently inhibits JAK2, FLT3, and CDK2 with IC₅₀ values of 13, 73, and 56 nM. It blocks cancer‑cell proliferation, suppresses tumor growth, and inhibits CYP2D6. The compound demonstrates high plasma protein binding, favorable Caco‑2 permeability, broad tissue distribution, and metabolic stability in liver microsomes. Zotiraciclib produces significant tumor‑growth inhibition in nude‑mouse models of colon cancer and lymphoma, supporting its application in studies of hematologic malignancies and solid tumors.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.