ZSTK474

SI-5344

ZSTK474, >98% (HPLC)

CAS No. : [475110-96-4]

MDL No. : MFCD08705334

IUPAC Name : 4,4'-(6-(2-(Difluoromethyl)-1H-benzo[d]imidazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : ZSTK474 inhibits class I PI3K isoforms with IC50 of 37 nM in a cell-free assay, mostly PI3Kδ. ZSTK474 showed potent antitumor activity in vivo against a human cancer xenograft without observable toxicity.

References : Yaguchi S. et al.: J. Natl Cancer Inst., 98(8), 545-556, 2006; Kong D. et al.: Cancer Sci., 98(10), 1638-1642, 2007; Kong D. et al.: Eur J Cancer., 45(5), 857-865, 2009; Marone R. et al.: Mol Cancer Res., 7(4), 601-613, 2009; Yang S. et al. PLoS One 6(10), e26343, 2011; Haruta K. et al.: Inflamm Res., 61(6), 551-562, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.