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Screening Compounds

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Screening Compounds

Screening CompoundsThe future of drug discovery is moving faster than ever—and it starts with smarter screening compounds. As AI driven design, DEL technologies, miniaturized HTS platforms, and fragment based discovery reshape early research, the demand for high quality, structurally diverse, IP advantaged chemical matter has never been higher. SynInnova Laboratories delivers screening libraries engineered for this new era: compounds with medicinal chemistry relevance, scaffold novelty, physicochemical balance, and synthetic tractability that translate into real downstream value.

Our collections span heterocycles, privileged scaffolds, fragments, lead like chemotypes, and emerging motifs designed to unlock new biological space. Each compound is curated for purity, stability, and optimization potential, ensuring seamless progression from hit identification to hit to lead development. By integrating cheminformatics, modern design principles, and scalable synthesis platforms, we provide discovery teams with reliable, discovery ready chemical matter that accelerates hit finding, reduces early stage risk, and strengthens the probability of identifying meaningful, developable leads.

In a landscape where speed, novelty, and quality define competitive advantage, SynInnova’s screening compounds offer a scientifically rigorous and commercially impactful foundation for productive drug discovery programs.

SynInnova is pleased to offer a portfolio of high demand screening compounds designed for modern drug discovery platforms. We also provide custom designed screening compounds tailored precisely to your project requirements, ensuring the right chemical matter for your specific biological targets and workflows.

For more information, please contact us at sales@syninnova.com.

1. Fragment Screening Compounds (Rule of 3)

Always in high demand for FBDD, as fragment based screening is standard across all major pharma and biotech discovery programs.

Top Fragments
  • 4-Aminopyrimidine
  • 3-Aminopyrazole
  • 2-Aminopyridine
  • 4-Hydroxypyrimidine
  • 3-Hydroxypyrazole
  • 4-Chloropyridine
  • 2-Fluoropyridine
  • 3-Fluoropyrimidine
  • Benzimidazole fragment
  • Indazole fragment

2. Covalent Screening Compounds (Electrophilic Warheads)

High demand driven by the rapid expansion of covalent drug discovery (KRAS, BTK, EGFR, and beyond).

Top Covalent Fragments
  • Acrylamide fragments
  • Chloroacetamide fragments
  • Sulfonyl fluoride fragments
  • Vinyl sulfone fragments
  • α-Cyanoacrylamide fragments
  • Epoxide fragments
  • Michael acceptor fragments
  • Isothiocyanate fragments
  • Boronic acid fragments
  • Aldehyde fragments

3. PROTAC Screening Compounds (Linkers + Ligands)

Massive demand as more than 100 companies actively advance degrader programs.

Top PROTAC Screening Compounds
  • PEG2 linker
  • PEG3 linker
  • PEG4 linker
  • Alkyl linker (C6-C10)
  • Rigid aromatic linker
  • VHL ligand (VH032)
  • CRBN ligand (pomalidomide analog)
  • CRBN ligand (lenalidomide analog)
  • IAP ligand
  • MDM2 ligand

4. Chemical Biology Screening Compounds (Photoaffinity + Click Chemistry)

High demand as chemical biology rapidly expands across proteomics, target ID, and probe development.

Top Chemical Biology Screening Compounds
  • Trifluoromethyl diazirine
  • Diazirinyl PEG2 amine
  • Diazirinyl PEG4 amine
  • Diazirinyl NHS ester
  • Diazirinyl maleimide
  • Azido PEG2
  • Azido PEG4
  • Alkyne PEG2
  • Tetrazine linker
  • DBCO linker

5. Fluorinated Screening Compounds

High demand because fluorine enhances potency, PK, metabolic stability, and selectivity.

Top Fluorinated Screening Compounds
  • CF3 pyrimidine
  • CF2H pyridine
  • CHF2 benzyl alcohol
  • Fluorinated aza indole
  • Fluorinated quinazoline
  • Fluorinated pyrazole
  • Fluorinated imidazopyridine
  • Fluorinated benzoxazole
  • Fluorinated benzothiazole
  • Fluorinated pyridazinone

6. Kinase Screening Compounds (ATP Mimetic Scaffolds)

High demand because kinases remain the number one drug target class globally.

Top Kinase Screening Compounds
  • Quinazoline core
  • Pyrimidine core
  • Pyrazolopyrimidine
  • Indazole core
  • Imidazopyridine core
  • Thienopyrimidine
  • Pyridazinone
  • Benzimidazole core
  • Isoquinoline core
  • Pyridine sulfonamide

7. GPCR Screening Compounds

High demand because GPCRs represent the largest and most biologically relevant receptor family.

Top GPCR Screening Compounds
  • Indole derivatives
  • Piperazine derivatives
  • Pyrrolidine derivatives
  • Benzylamines
  • Phenethylamines
  • Tryptamine analogs
  • Isoquinoline derivatives
  • Benzimidazole derivatives
  • Pyridine amines
  • Pyrimidine amines

8. Phenotypic Screening Compounds (Cell Based Assays)

High demand as phenotypic screening resurges across oncology, CNS, and inflammation.

Top Phenotypic Screening Compounds
  • Heterocyclic amines
  • Aromatic aldehydes
  • Aromatic ketones
  • Sulfonamides
  • Boronic acids
  • Chiral amines
  • Chiral alcohols
  • Chiral acids
  • Small heterocycles
  • Fluorinated aromatics

9. Isotopic Screening Compounds (Metabolism + PK/PD)

High demand because isotopic compounds are essential for ADMET, PK/PD, and mass spec based profiling.

Top Isotopic Screening Compounds
  • D5 benzaldehyde
  • D3 acetophenone
  • D6 phenol
  • 13C benzaldehyde
  • 13C pyridine
  • 15N pyrimidine
  • D labelled heterocycles
  • D labelled diazirines
  • D labelled PROTAC linkers
  • D labelled sulfonamides

10. Impurity Screening Compounds (CMC + QC)

High demand because CMC teams outsource impurity standards continuously—regulatory driven and recession proof.

Top Impurity Screening Compounds
  • N-oxide impurity
  • Des-methyl impurity
  • Des-fluoro impurity
  • Hydroxylated impurity
  • Carboxylated impurity
  • Oxidative impurity
  • Hydrolytic impurity
  • Photolytic impurity
  • Phase I metabolite
  • Phase II metabolite