SynInnova Laboratories Inc.

SI-1799

Roflumilast, 98% (HPLC)

CAS No. :

[162401-32-3]

MDL No. :

MFCD00938270

Synonyms : 3-(Cyclopropylmethoxy)-N-(3,5-dichloro-4-pyridinyl)-4- (difluoromethoxy)benzamide

Price and Availability
Pack Size	Price in USD	Quantity	Availability	Shipping Status
5MG	50.00	- +	In Stock	Estimated to Ship on 05.16.2024
10MG	70.00	- +	In Stock	Estimated to Ship on 05.16.2024
50MG	200.00	- +	In Stock	Estimated to Ship on 05.16.2024

Chemical Properties
Mol. Formula : C₁₇H₁₄Cl₂F₂N₂O₃	Mol. Weight : 403.21
Appearance : White to Off-white solid	Melting Point : Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Roflumilast is a selective PDE4 inhibitor with IC50s of 0.7, 0.9, 0.7, and 0.2 nM for PDE4A1, PDEA4, PDEB1, and PDEB2, respectively, without affecting PDE1, PDE2, PDE3 or PDE5 isoenzymes from various cells.

References : Hatzelmann A. et al.: Pulm Pharmacol Ther., 23 (4), 235-256, 2010; Rabe K. F. Br. J. Pharmacol., 163 (1), 53-67, 2011; Hatzelmann A. et al.: J. Pharmacol Exp Ther., 297 (1), 267-279, 2001; Richmond B. W. et al.: Nat. Commun. 7, 11240, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SI-1799

Product Name : Roflumilast

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SI-1799

Roflumilast, 98% (HPLC)

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