[955272-06-7]    

MFCD09961532

Synonyms : 2-(2-Chlorophenyl)-4-methyl-5-(pyridin-2-ylmethyl)-1,2-dihydro-3H-pyrazolo[4,3-c]pyridine-3,6(5H)-dione

Applications : GKT-136901 is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT-136901 is also a selective and direct scavenger of peroxynitrite. GKT-136901 can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT-136901 also has anti-inflammatory activity.

References : Laleu B. et al.: J. Med Chem., 53(21), 7715-30, 2010; Teixeira G. et al.: Br. J. Pharmacol., 174(12), 1647-1669, 2017; Schildknecht S. et al.: Curr Med Chem., 21(3), 365-76, 2014; Sedeek M. et al. Am J. Physiol Renal Physiol., 299(6), F1348-58, 2010; Hwang J. S. et al.: Life Sci., 256, 117917, 2020;
Sedeek M. et al. Clin Sci (Lond). 124(3), 191-202, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.