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SI-5153

Talmapimod hydrochloride, >98% (HPLC)

CAS No. : 
[309915-12-6]    
Synonyms : 2-(6-Chloro-5-((2S,5R)-4-(4-fluorobenzyl)-2,5-dimethylpiperazine-1-carbonyl)-1-methyl-1H-indol-3-yl)-N,N-dimethyl-2-oxoacetamide hydrochloride; SCIO-469 hydrochloride

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Talmapimod hydrochloride is not in stock, can be available through custom synthesis. The estimated lead-time is 4-6 weeks. The product will be characterized by NMR and MS analysis. Purity (HPLC) is usually >98%. COA, QC data, SDS will be provided along with the product. For information on pricing and availability please contact us at sales@syninnova.com or submit the following Bulk Quote Request. We respond promptly. Thank You!
Chemical Properties
C27H30ClFN4O3 . HCl 549.47
Solid Not available
For Laboratory research use only, not for drug, household or other uses.
Applications : Talmapimod hydrochloride is an orally active, selective, and ATP-competitive p38α inhibitor with an IC50 of 9 nM. Talmapimod hydrochloride shows about 10-fold selectivity over p38β, and at least 2000-fold selectivity over a panel of 20 other kinases, including other MAPKs. It has potential for immunomodulating, anti-inflammatory, and antineoplastic activities.
References : Hideshima T. et al.: Oncogene 23(54), 8766-8776, 2004; Navas T. et al.: Leuk Lymphoma 49(10), 1963-1975, 2008; Vanderkerken K. et al.: Cancer Res., 67(10), 4572-4577, 2007; Medicherla S. et al.: Anticancer Res., 28(6A), 3827-3833, 2008.
Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.
Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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Product ID : SI-5153

Product Name : Talmapimod hydrochloride

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Site is under construction and it will coming soon. Please contact us at sales@syninnova.com for COA. Thank you!

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